The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity

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The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity.

Cranial neural crest (CNC) cells are a transient population of stem cells that originate at the border of the neural plate and the epidermis, and migrate ventrally to contribute to most of the facial structures including bones, cartilage, muscles and ganglia. ADAM13 is a cell surface metalloprotease that is essential for CNC cell migration. Here, we show in Xenopus laevis embryos that the Wnt r...

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ژورنال

عنوان ژورنال: Journal of Cell Science

سال: 2015

ISSN: 1477-9137,0021-9533

DOI: 10.1242/jcs.163063